Various - sequences 27 - 10th anniversary special edition - Sequences and Series - Worked Examples


With their high mRNA binding affinity and exquisite specificity, Morpholinos yield reliable and predictable results. Depending on the oligo sequence selected, they either can block translation initiation in the cytosol (by targeting the 5' UTR through the first 25 bases of coding sequence), can modify pre-mRNA splicing in the nucleus (by targeting splice junctions or splice regulatory sites) or can inhibit miRNA maturation and activity (by targeting pri-miRNA or mature miRNA), as well as more exotic applications such as ribozyme inhibition, modifying poly-A tailing, blocking RNA translocation sequences or translational frameshifting. Morpholinos have been shown effective in animals, protists, plants and bacteria.

Five is conjectured to be the only odd untouchable number and if this is the case then five will be the only odd prime number that is not the base of an aliquot tree.


Various - Sequences 27 - 10th Anniversary Special EditionVarious - Sequences 27 - 10th Anniversary Special EditionVarious - Sequences 27 - 10th Anniversary Special EditionVarious - Sequences 27 - 10th Anniversary Special Edition

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